The m6A demethylase FTO suppresses glioma proliferation by regulating the EREG/PI3K/Akt signaling pathway
Our findings establish FTO as a tumor suppressor in glioma. It inhibits proliferation by destabilizing EREG mRNA in an m6A-dependent manner, thereby inactivating the PI3K/Akt signaling cascade. These results highlight FTO as a potential prognostic biomarker and a promising therapeutic target for glioma.
Authors
- Junwei Ren
- Li‐Hui Cao (ORCID: https://orcid.org/0000-0002-3676-0242)
- Yue Liu (ORCID: https://orcid.org/0000-0002-6670-7055)
- Shen Zhang (ORCID: https://orcid.org/0000-0002-6429-8008)
- Xiao Liu
- Caili Li (ORCID: https://orcid.org/0000-0003-0967-6077)
- Yong Zhai
Institutions
- Hubei University of Arts and Science (CN)
- Xiang Yang No.1 People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fcell.2025.1667990
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81