Inhibitory and excitatory conditioned cues associated with alcohol differentially modulate the nucleus accumbens shell: involvement of 5-HT7 receptors
Overall, the data suggest that there are distinct neurocircuits within the AcbSh that mediating the effects of excitatory and inhibitory conditioned cues on motivated behavior. While this work highlights a complex interaction of several neurotransmitter systems, it may also suggest a potential role for behavioral therapies involving extinction training and 5-HT<sub>7</sub> receptor activation as potential targets for the treatment of cue-induced drug-seeking behavior.
Authors
- Christopher P. Knight
- Eric A. Engleman
- Philip L. Johnson
- William A. Truitt (ORCID: https://orcid.org/0000-0002-0614-5206)
- William J. McBride (ORCID: https://orcid.org/0000-0001-8894-533X)
- Sheketha R. Hauser (ORCID: https://orcid.org/0000-0002-0023-331X)
- Gerald A. Deehan (ORCID: https://orcid.org/0000-0002-9211-2610)
- Robert A. Waeiss (ORCID: https://orcid.org/0000-0003-1232-3766)
- Richard L. Bell (ORCID: https://orcid.org/0000-0002-0525-0485)
- Zachary A. Rodd (ORCID: https://orcid.org/0000-0002-8105-1920)
Institutions
- East Tennessee State University (US)
- Neurosciences Institute (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fpsyt.2025.1634350
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Alcohol Abuse and Alcoholism