Pde5a deficiency prevents diet-induced obesity via adipose cAMP-PKA activation enhancing fat browning
Our study identifies PDE5A as a previously unrecognized regulator of thermogenesis and energy balance. Targeting PDE5A may therefore represent a promising adjuvant therapeutic approach for the treatment of metabolic disorders.
Authors
- Serena Monti (ORCID: https://orcid.org/0000-0002-8777-7837)
- Federica Campolo (ORCID: https://orcid.org/0000-0002-9290-874X)
- A. Patriarca (ORCID: https://orcid.org/0009-0005-4471-8107)
- Ottavia Giampaoli (ORCID: https://orcid.org/0000-0003-1336-3102)
- Mauro Giorgi (ORCID: https://orcid.org/0000-0002-2923-4893)
- Federica Barbagallo (ORCID: https://orcid.org/0000-0002-2972-370X)
- Lino Tessarollo (ORCID: https://orcid.org/0000-0001-6420-772X)
- Biagio Palmisano (ORCID: https://orcid.org/0000-0002-1287-5256)
- Mara Riminucci (ORCID: https://orcid.org/0000-0002-8643-9211)
- Maria Rita Assenza (ORCID: https://orcid.org/0000-0002-3725-7163)
- Fabio Naro (ORCID: https://orcid.org/0000-0003-0572-5900)
- Silvia Cardarelli (ORCID: https://orcid.org/0000-0001-6798-6220)
- Antonio Filippini (ORCID: https://orcid.org/0000-0001-8453-287X)
- Mary Anna Venneri (ORCID: https://orcid.org/0000-0002-0687-8135)
- Sandra Albanese (ORCID: https://orcid.org/0000-0002-7112-273X)
- Fabio Sciubba (ORCID: https://orcid.org/0000-0002-1982-2712)
- Andrea Lenzi (ORCID: https://orcid.org/0000-0002-7711-0465)
- Anna Maio (ORCID: https://orcid.org/0000-0003-4605-9684)
- Francesca Sciarra (ORCID: https://orcid.org/0000-0001-9492-296X)
- Maurilio Sampaolesi (ORCID: https://orcid.org/0000-0002-2422-3757)
- Susanna Dolci (ORCID: https://orcid.org/0000-0002-6864-3673)
- Eleonora Poggiogalle (ORCID: https://orcid.org/0000-0003-0862-5892)
- Flavio Rizzo (ORCID: https://orcid.org/0000-0003-2191-3311)
- Alfredo Miccheli
- Andrea Maria Isidori (ORCID: https://orcid.org/0000-0002-9037-5417)
- Daniele Gianfrilli
Institutions
- University of Rome Tor Vergata (IT)
- National Institutes of Health (US)
- Università degli Studi di Enna Kore (IT)
- CEINGE Biotecnologie Avanzate Franco Salvatore (Italy) (IT)
- Institute of Biostructure and Bioimaging (IT)
- National Cancer Institute (US)
- Cancer Genetics (United States) (US)
- Center for Cancer Research (US)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1016/j.molmet.2025.102243
- Citations
- 2
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Sapienza Università di Roma