Comparison of tetrabenazine, tiapride and olanzapine in Huntington's disease: a one-year French randomized multicenter study (Neuro-HD)
Olanzapine improved chorea, behavior, and irritability, although with a slight increase in rigidity. Tetrabenazine confirmed efficacy for chorea but was associated with mood disorders and drowsiness, while tiapride reduced irritability. These results underscore the importance of symptom-specific, individualized treatment.
Authors
- Étienne Audureau (ORCID: https://orcid.org/0000-0002-6166-149X)
- Christine Tranchant (ORCID: https://orcid.org/0000-0002-2895-1292)
- Alexandra Dürr (ORCID: https://orcid.org/0000-0002-8921-7104)
- Cécilia Marelli (ORCID: https://orcid.org/0000-0002-9543-6311)
- Anne‐Catherine Bachoud‐Lévi (ORCID: https://orcid.org/0000-0003-3000-2210)
- Katia Youssov (ORCID: https://orcid.org/0000-0001-6055-2614)
- Isabelle Bénatru (ORCID: https://orcid.org/0000-0002-3642-6914)
- Jean‐Philippe Azulay (ORCID: https://orcid.org/0000-0001-6624-3329)
- C. Simonin (ORCID: https://orcid.org/0000-0002-2282-4372)
- Christophe Verny (ORCID: https://orcid.org/0000-0003-2420-2806)
- Jérémie Pariente
- Pierre Krystkowiak
Institutions
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- École Normale Supérieure - PSL (FR)
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Institut de génétique et de biologie moléculaire et cellulaire (FR)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre de Recherche Jean Pierre Aubert (FR)
- Abu Dhabi Health Services (AE)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Institut de Neurosciences de la Timone (FR)
- Institut du Cerveau (FR)
- Hôpital Paule de Viguier (FR)
- Institut Mondor de Recherche Biomédicale (FR)
- Mécanismes moléculaires dans les démences neurodégénératives (FR)
Publication Details
- Journal
- Parkinsonism & Related Disorders
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1016/j.parkreldis.2025.108017
- Citations
- 1
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.91