Laboratory Investigation of Lipid Metabolic Reprogramming in Pulpitis: The Linolenic Acid– <scp>FASN</scp> – <scp>NR4A1</scp> Axis in Modulating Dental Pulp Inflammation
This study reveals a pathological FASN-LA-NR4A1 regulatory axis linking lipid metabolism to inflammatory amplification in pulpitis. Dual targeting of fatty acid synthesis and lipid depletion-through FASN inhibition and LA supplementation-attenuates inflammation via NR4A1-dependent mechanisms. These findings lay the groundwork for metabolic approaches to modulate inflammation in endodontics.
Authors
- Qiangqiang Zhou (ORCID: https://orcid.org/0000-0001-9407-9925)
- Mengqi Zhou
- Changyi Li (ORCID: https://orcid.org/0000-0003-3667-3007)
- Xin Sui (ORCID: https://orcid.org/0009-0007-3266-1291)
- Xiaoling Wei
- Huaxing Xu
Institutions
- Fudan University (CN)
- Shanghai Stomatological Hospital (CN)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1111/iej.70026
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00