Current evidence of sinonasal carcinoma for clinical practitioners. Part 1

Sinonasal carcinoma (SNC) is the most common malignant tumor of the nasal cavity and paranasal sinuses. SNC includes the following pathological subtypes: sinonasal squamous cell carcinoma (snSCC), sinonasal adenocarcinoma (snAC), sinonasal adenoid cystic carcinoma (snACC), olfactory neuroblastoma (ONB), sinonasal neuroendocrine carcinoma (snNEC), nuclear protein in testis carcinoma (NUT), and sinonasal undifferentiated carcinoma (snUC). Due to its rarity and diversity, SNC is poorly understood, and its management is not supported by randomized clinical trials, but rather by case series, single-center reports, or meta-analyses. The aim of this study is to comprehensively present the epidemiology and etiology, along with the clinical course of the disease, as well as methods and outcomes of treatment in patients with SNC. It was believed that this elaboration may support the daily clinical practice of those who care for patients with SNC.