Formosulfathiazole: A Structural Revision
Formosulfathiazole (FSTz) is a synthetic active pharmaceutical ingredient (API) prepared by condensation of sulfathiazole with formaldehyde. Originally described for the first time in 1948, it is currently used for the treatment of bacterial and protozoal infections in cattle and pets, acting as a prodrug slowly releasing the sulfamidic sulfathiazole and formaldehyde. A systematic analysis of FSTz allowed to revise the originally believed undefined polymeric structure and uncovered the intriguing cyclophane skeleton of a well-defined cyclodimeric condensation product.
Authors
- Giovanni Battista Giovenzana (ORCID: https://orcid.org/0000-0001-7117-0347)
- Fabio Travagin (ORCID: https://orcid.org/0000-0003-3003-989X)
- Valentina Colombo (ORCID: https://orcid.org/0000-0003-0263-4456)
- Ivana Miletto (ORCID: https://orcid.org/0000-0002-0313-7614)
- Michele Castaldi (ORCID: https://orcid.org/0000-0002-1751-0846)
- Toni Grell (ORCID: https://orcid.org/0000-0001-9162-6487)
- Christian R. Göb (ORCID: https://orcid.org/0000-0002-2354-4153)
- Geo Paul (ORCID: https://orcid.org/0000-0002-0944-0016)
- Marco Vandone (ORCID: https://orcid.org/0000-0003-2835-4663)
- Claudio Maestri (ORCID: https://orcid.org/0009-0004-9175-9713)
- Silvia Zampini
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Universidad Pontificia Bolivariana (CO)
- University of Milan (IT)
- Toray International Europe (Germany) (DE)
- Novamont (Italy) (IT)
Publication Details
- Journal
- ChemPlusChem
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1002/cplu.202500406
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Milano
- European Commission
- Papua New Guinea University of Technology