Physicochemical Properties of a Water-Soluble Adduct of C<sub>60</sub> with <scp>l</scp>-Cysteine for Biomedical Applications
As a result of a comprehensive study of the physicochemical properties of the C<sub>60</sub>-l-cysteine aqueous solutions, practically significant results were obtained, which underlie the understanding of the mechanisms of biological action and biocompatibility. It was shown that the adduct of fullerene C<sub>60</sub> with l-cysteine is compatible with water and aqueous solutions and at the same time is amphiphilic. Aqueous solutions are strongly associated and, depending on the concentration, associates of various orders are formed up to the micron size; dilute solutions have high negative partial volumes, which indicate a strong structure. The adduct does not exhibit cytotoxicity, possesses antiradical activity, and reversibly binds to human serum albumin. The obtained data demonstrates the complexity of the systems under study and the prospects for their application in medicinal chemistry and biomedical materials science.
Authors
- Dmitry Nerukh (ORCID: https://orcid.org/0000-0001-9005-9919)
- I. V. Murin (ORCID: https://orcid.org/0000-0003-1869-7590)
- Alexander V. Akentiev (ORCID: https://orcid.org/0000-0001-7327-6348)
- Dilfuza Rabbimova
- Ilnaz T. Rakipov (ORCID: https://orcid.org/0000-0001-5836-9562)
- Natalia V. Petukhova (ORCID: https://orcid.org/0000-0001-6397-824X)
- Vladimir V. Sharoyko (ORCID: https://orcid.org/0000-0002-3717-0471)
- Konstantin N. Semenov (ORCID: https://orcid.org/0000-0003-2239-2044)
- Nikolay A. Charykov (ORCID: https://orcid.org/0000-0002-4744-7083)
- Andrey V. Petrov (ORCID: https://orcid.org/0000-0002-4650-4891)
- Gleb O. Iurev (ORCID: https://orcid.org/0000-0003-3330-6324)
- Kirill V. Timoshchuk
- Dilafruz K. Kholmurodova
- Ali Mlhem
- Lola B. Mahmudova
- Gulafzal U. Amonova
Institutions
- Aston University (GB)
- St Petersburg University (RU)
- Kazan Federal University (RU)
- First Pavlov State Medical University of St. Petersburg (RU)
- Samarkand State Medical Institute (UZ)
- Toronto Metropolitan University (CA)
- St. Petersburg State Technological Institute (RU)
Publication Details
- Journal
- The Journal of Physical Chemistry Letters
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1021/acs.jpclett.5c01859
- Citations
- 1
- Primary Topic
- Fullerene Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Engineering and Physical Sciences Research Council
- H2020 Marie Skłodowska-Curie Actions