Extra-gastrointestinal stromal tumor of the prostate — a case report and literature review

Extra-gastrointestinal stromal tumors (EGISTs) primarily originate outside the gastrointestinal tract and are not associated with the walls of the stomach or intestines. They typically arise from the omentum, mesentery, peritoneum, retroperitoneum, and genitourinary regions. However, EGISTs originating from the prostate are exceedingly rare. Herein, a case is presented of an EGIST arising from prostatic tissue. The patient underwent radical prostatectomy. Histopathological examination revealed spindle-shaped tumor cells. Immunohistochemical analysis demonstrated positive expression of CD117, DOG-1, and CD34, leading to the diagnosis of a gastrointestinal stromal tumor (GIST). Radiologic staging showed no evidence of residual disease or metastasis; however, due to the high-risk nature of the tumor, adjuvant imatinib therapy was initiated. No recurrence or metastasis was observed during a one-year follow-up period, and the patient continues to be monitored regularly. This article also provides a comprehensive review of the clinical characteristics, histopathology, and treatment of EGIST cases reported in the literature.