Tamoxifen-induced hepatotoxicity and symptomatic tarlov cyst in a breast cancer survivor — coexistence or consequence?

Invasive breast carcinoma is among the most prevalent malignancies affecting women globally. This case presents a 47-year-old female diagnosed with invasive breast carcinoma, treated with mastectomy, chemotherapy, targeted therapy, and hormonal therapy. During follow-up, she developed hepatic dysfunction attributed to tamoxifen and subsequently experienced lower back pain due to a Tarlov cyst. The case underscores the importance of comprehensive and sustained surveillance in breast cancer survivors for the early detection and management of treatment-related complications and musculoskeletal manifestations.

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Publication Details

Journal
Oncology in Clinical Practice
Published
2025-09-03
DOI
https://doi.org/10.5603/ocp.106126
Primary Topic
Cancer Treatment and Pharmacology
Type
article
Field-Weighted Citation Impact
0.00
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article

Tamoxifen-induced hepatotoxicity and symptomatic tarlov cyst in a breast cancer survivor — coexistence or consequence?

Gülnihal Deniz, Ömer Esmez, Merve Yıldız Esmez
Oncology in Clinical Practice
Cancer Treatment and Pharmacology
article

Tamoxifen-induced hepatotoxicity and symptomatic tarlov cyst in a breast cancer survivor — coexistence or consequence?

Gülnihal Deniz, Ömer Esmez, Merve Yıldız Esmez
article en

Abstract

Invasive breast carcinoma is among the most prevalent malignancies affecting women globally. This case presents a 47-year-old female diagnosed with invasive breast carcinoma, treated with mastectomy, chemotherapy, targeted therapy, and hormonal therapy. During follow-up, she developed hepatic dysfunction attributed to tamoxifen and subsequently experienced lower back pain due to a Tarlov cyst. The case underscores the importance of comprehensive and sustained surveillance in breast cancer survivors for the early detection and management of treatment-related complications and musculoskeletal manifestations.

Oncology in Clinical PracticeVol. 22(0)
Fırat University (TR), Erzurum Technical University (TR), Elazığ Eğitim ve Araştırma Hastanesi (TR)
Openalex Percentile: Top 67%
Cancer Treatment and Pharmacology
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Tamoxifen-induced hepatotoxicity and symptomatic tarlov cyst in a breast cancer survivor — coexistence or consequence? — Gülnihal Deniz, Ömer Esmez, et al. · Oncology in Clinical Practice (2025) | TGRS Research Map | TGRS