A Novel Case of Nerve Biopsy Proven Wild Type Transthyretin (<scp>TTR</scp>) Amyloidosis
This case confirms the presence of ATTRwt deposition directly in nerve tissue as the likely cause of the patient's large fiber and multiple mononeuropathies, expanding our current understanding of ATTRwt-associated disease. Proving the direct association of ATTRwt and neuropathy may open up amyloid-specific treatments for this disease.
Authors
- Catherine Daley
- Michael Skolka (ORCID: https://orcid.org/0009-0006-5155-4371)
- JaNean Engelstad
- Karen L. Rech (ORCID: https://orcid.org/0000-0001-6770-2339)
- Peter James Dyck (ORCID: https://orcid.org/0000-0002-1704-4312)
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- Northwestern Medicine (US)
Publication Details
- Journal
- Journal of the Peripheral Nervous System
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/jns.70056
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00