Early and Stable Mouse Model of Amphotericin B‐Induced Acute Kidney Injury: Application of Continuous Non‐Invasive <scp>GFR</scp> Monitoring
Continuous GFR monitoring enables sensitive detection of early renal dysfunction and reveals distinct nephrotoxic profiles between AmB-D and ABCD. This pharmacologically relevant model provides a powerful tool for preclinical nephrotoxicity assessment and for quantitatively comparing the renal safety of different drug formulations.
Authors
- Yinghao Luo
- Lifeng Shen
- Qianqian Zhang (ORCID: https://orcid.org/0000-0001-6481-0780)
- Xinran Wang (ORCID: https://orcid.org/0000-0002-5846-4743)
- Yu‐Chen Song
- Yanqi Liu (ORCID: https://orcid.org/0000-0003-3499-0201)
- Xiao Yu
- Yuxi Liu (ORCID: https://orcid.org/0000-0002-6105-8594)
- Changsong Wang (ORCID: https://orcid.org/0009-0006-2670-3945)
- Kaijiang Yu (ORCID: https://orcid.org/0000-0002-8429-6616)
- Yu Xin
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Clinical and Experimental Pharmacology and Physiology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1111/1440-1681.70071
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China