Estimating the preclinical Alzheimer's disease course with multimodal data
Cognitive time (c-time) represents an individual's distance from a hinge point of cognitive decline. C-time and time-to-amyloid beta (Aβ)+ were moderately positively correlated. Inferior temporal tau and cortical thickness mediated the effect between c-time and time-to-Aβ+. C-time more closely associates with tau, brain atrophy, and cortical thickness.
Authors
- Heidi I.L. Jacobs (ORCID: https://orcid.org/0000-0001-7620-3822)
- Aaron P. Schultz (ORCID: https://orcid.org/0000-0002-0418-0999)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Keith A. Johnson (ORCID: https://orcid.org/0000-0002-4685-5173)
- Zahra Shirzadi (ORCID: https://orcid.org/0000-0001-6854-9356)
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- Wai‐Ying Wendy Yau (ORCID: https://orcid.org/0000-0002-7597-7647)
- Karly Alex Cody (ORCID: https://orcid.org/0000-0001-5996-2560)
- Bernard Hanseeuw (ORCID: https://orcid.org/0000-0002-3102-6778)
- Hyun‐Sik Yang (ORCID: https://orcid.org/0000-0002-8318-0443)
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Julie C. Price
- Rory Boyle (ORCID: https://orcid.org/0000-0003-0787-6892)
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Michael J Properzi (ORCID: https://orcid.org/0000-0001-7855-2372)
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- Hannah M Klinger
- Michelle E. Farrell
- Dorene M. Rentz
- Reisa A. Sperling
- Diana L. Townsend
Institutions
- Brigham and Women's Hospital (US)
- Cliniques Universitaires Saint-Luc (BE)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- The University of Melbourne (AU)
- Palo Alto University (US)
- Massachusetts General Hospital (US)
- Pennsylvania Academic Library Consortium (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Australian Psychological Society (AU)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70658
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Foundation for the National Institutes of Health
- Alzheimer's Association
- University of Melbourne
- National Institutes of Health
- National Institute on Aging