Diffuse large B-cell lymphoma masquerading as a pressure ulcer

An 84-year-old man with a history of amputation and follicular lymphoma developed a non-healing ulcer on his stump, initially diagnosed as a pressure ulcer cause by the clinic and lack of B-symptoms. Despite wound care, the lesion worsened. A biopsy revealed de novo diffuse large B-cell lymphoma (DLBCL), non-germinal center subtype. This case highlights the need for malignancy screening in chronic wounds, particularly in high-risk patients, emphasizing the importance of biopsy when standard treatment fails.