Multicenter Development of a Clinical-Molecular Nomogram for Predicting Survival in Lung Cancer Brain Metastasis Patients
This study establishes a validated prognostic model integrating tumor burden, EGFR mutation status, and metastatic patterns. It demonstrates that EGFR-guided TKI therapy and bone metastasis surveillance critically influence LCBM outcomes. The nomogram provides a quantifiable framework for risk-adapted therapeutic decisions, advancing precision oncology in neuro-oncology practice.
Authors
- Sifang Chen (ORCID: https://orcid.org/0000-0001-5198-1361)
- Weili Zhao (ORCID: https://orcid.org/0000-0002-6834-1616)
- Zhenwei Lu (ORCID: https://orcid.org/0000-0001-9614-3038)
- Jiawei He (ORCID: https://orcid.org/0000-0003-1133-7429)
- Lixia Chen (ORCID: https://orcid.org/0000-0003-2196-1428)
- Xinguang Qiu (ORCID: https://orcid.org/0000-0001-9574-9812)
- Xiaoping Zhou (ORCID: https://orcid.org/0000-0003-2831-635X)
- Zhilan Peng (ORCID: https://orcid.org/0000-0003-4748-8675)
- Xuewei Xia (ORCID: https://orcid.org/0000-0002-6447-8906)
- Jingjing Shi (ORCID: https://orcid.org/0009-0007-7135-0568)
- Chongfei Li
- Zhanxiang Wang
Institutions
- Fujian Medical University (CN)
- Guilin Medical University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Ganzhou People's Hospital (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
Publication Details
- Journal
- Cancer Management and Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/cmar.s538752
- Citations
- 1
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52