Paeoniflorin Combined with Neural Stem Cell Transplantation for Parkinson’s Disease: Dual Mechanism of Cell Therapy and Inflammation Regulation
Paeoniflorin lessens inflammatory damage to transplanted cells, promotes survival and differentiation, and outperforms mDA-only transplantation for neuronal survival and functional recovery. By regulating inflammation, PF optimizes the neural microenvironment, offering new perspectives for combined cell transplantation therapy in PD.
Authors
- Ruen Liu (ORCID: https://orcid.org/0000-0002-2405-5597)
- Shijun Peng
- Lepeng Wang (ORCID: https://orcid.org/0000-0002-6735-8299)
- Jia Ouyang
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/dddt.s524050
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68