The Dual Role of RBBP7 in Esophageal Squamous Cell Carcinoma: Cell Context-Dependent Impacts on Proliferation and Radiosensitivity
RBBP7 is highly expressed in ESCC, and it exerts cell context-dependent dual roles in ESCC, leading to differences in cellular radiosensitivity, possibly mediated through STAT3 signaling. This dichotomy highlights its potential as a differentiation status-specific therapeutic target.
Authors
- Zhiyu Ma (ORCID: https://orcid.org/0000-0002-9284-4328)
- Guangwen Zhu (ORCID: https://orcid.org/0000-0003-1338-0367)
- Heng Tang (ORCID: https://orcid.org/0000-0003-0959-3650)
- Shuai Lü (ORCID: https://orcid.org/0000-0001-6171-5032)
- Hui Yao (ORCID: https://orcid.org/0000-0002-4609-6437)
- Hao Liu (ORCID: https://orcid.org/0000-0003-2396-2029)
- Yafen Li (ORCID: https://orcid.org/0000-0002-3334-7823)
Institutions
- Anhui Academy of Coal Science (CN)
- China Coal Technology and Engineering Group Corp (China) (CN)
Publication Details
- Journal
- OncoTargets and Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/ott.s535750
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00