Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease

Clonal haematopoiesis of indeterminate potential is a predictor of mortality in CAD patients. TET2 mutations promote a pro-atherogenic macrophage phenotype via LDLR up-regulation and inflammatory activation, linking epigenetic dysregulation to adverse outcomes in CAD.

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Publication Details

Journal
European Heart Journal
Published
2025-08-04
DOI
https://doi.org/10.1093/eurheartj/ehaf602
Citations
6
Primary Topic
Acute Myeloid Leukemia Research
Type
article
Field-Weighted Citation Impact
10.62

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article

Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease

Wesley Abplanalp, Torsten Haferlach, Ke Hao, David M. Leistner et al.
6 citations
European Heart Journal
Acute Myeloid Leukemia Research
10.62
article

Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease

Wesley Abplanalp, Torsten Haferlach, Ke Hao, David M. Leistner, Heribert Schunkert, Hendrik B. Sager, Maria Wahle, Johannes Krefting, Thorsten Kessler, Adnan Kastrati, Shaneice Mitchell, Claudia Haferlach, Stefanie Dimmeler, Gregor Hoermann, Wolfgang Köenig, Irina Pugach, Lars Mäegdefessel, Shaunak Adkar, Christian Joerg Braun, Angela Ma, Gerard Pasterkamp, Nicholas J. Leeper, Manja Meggendorfer, Matthias Graw, Ingo Hilgendorf, Wolfgang Kern, Dario Bongiovanni, J. Brett Heimlich, Sander W. van der Laan, Florian Bassermann, Andreas M. Zeiher, Judith S. Hecker, Johan Björkegren, Florian Leuschner, Salvatore Cassese, Arno Ruusalepp, Kaylin C.A. Palm, Siddhartha Jaiswal, Julia Fleig, Michal Mokrý, Matthias Schwab, Felix Voll, Sophia Steigerwald, Moritz von Scheidt, Sebastian Cremer, Sabine Bauer, Jason C. Kovacic, Matthias Mann, Lilith Oldenbuettel, Zhifen Chen, Christian Frieß, Charalampos Sofokleous
article en
6 citations

Abstract

Clonal haematopoiesis of indeterminate potential is a predictor of mortality in CAD patients. TET2 mutations promote a pro-atherogenic macrophage phenotype via LDLR up-regulation and inflammatory activation, linking epigenetic dysregulation to adverse outcomes in CAD.

European Heart JournalVol. 47(4)
Goethe University Frankfurt (DE), Augsburg University (US), Karolinska University Hospital (SE), Humanitas University (IT), University of Augsburg (DE), Utrecht University (NL), Victor Chang Cardiac Research Institute (AU), Heidelberg University (DE), Cardiovascular Institute of the South (US), Frankfurt Institute for Advanced Studies (DE), University Hospital Augsburg (DE), Tartu University Hospital (EE), TUM Klinikum (DE), Karolinska Institutet (SE), University Medical Center Utrecht (NL), LMU Klinikum (DE), UNSW Sydney (AU), Munich Leukemia Laboratory (Germany) (DE), Deutsches Herzzentrum der Charité (DE), St Vincent's Clinic (AU), German Centre for Cardiovascular Research (DE), Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE), Stanford Medicine (US), Deutsches Herzzentrum München (DE), Max Planck Institute of Biochemistry (DE), DKFZ-ZMBH Alliance (DE), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Clinical Gene Networks (Sweden) (SE), University of Tartu (EE), Ludwig-Maximilians-Universität München (DE), Vanderbilt University Medical Center (US), Stanford University (US), Icahn School of Medicine at Mount Sinai (US)
American Heart Association, Deutsches Zentrum für Herz-Kreislaufforschung, Corona-Stiftung, European Commission, Deutsche Forschungsgemeinschaft, Fondation Leducq, Bundesministerium für Bildung und Forschung, Vetenskapsrådet, Deutsche Herzstiftung, NSW Ministry of Health, Servier, National Institutes of Health, National Heart, Lung, and Blood Institute
Openalex Percentile: Top 2%
Acute Myeloid Leukemia Research
10.62
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