Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease
Clonal haematopoiesis of indeterminate potential is a predictor of mortality in CAD patients. TET2 mutations promote a pro-atherogenic macrophage phenotype via LDLR up-regulation and inflammatory activation, linking epigenetic dysregulation to adverse outcomes in CAD.
Authors
- Wesley Abplanalp (ORCID: https://orcid.org/0000-0001-5996-8997)
- Torsten Haferlach
- Ke Hao (ORCID: https://orcid.org/0000-0002-1815-9197)
- David M. Leistner (ORCID: https://orcid.org/0000-0002-4351-420X)
- Heribert Schunkert (ORCID: https://orcid.org/0000-0001-6428-3001)
- Hendrik B. Sager (ORCID: https://orcid.org/0000-0002-0197-6553)
- Maria Wahle (ORCID: https://orcid.org/0000-0003-2079-4402)
- Johannes Krefting (ORCID: https://orcid.org/0000-0002-7755-0954)
- Thorsten Kessler (ORCID: https://orcid.org/0000-0003-3326-1621)
- Adnan Kastrati (ORCID: https://orcid.org/0000-0003-4341-891X)
- Shaneice Mitchell (ORCID: https://orcid.org/0000-0001-9297-781X)
- Claudia Haferlach (ORCID: https://orcid.org/0000-0002-6333-5049)
- Stefanie Dimmeler (ORCID: https://orcid.org/0000-0002-1045-2436)
- Gregor Hoermann (ORCID: https://orcid.org/0000-0002-7374-4380)
- Wolfgang Köenig (ORCID: https://orcid.org/0000-0002-2064-9603)
- Irina Pugach
- Lars Mäegdefessel (ORCID: https://orcid.org/0000-0001-5228-2634)
- Shaunak Adkar (ORCID: https://orcid.org/0000-0002-8893-2413)
- Christian Joerg Braun (ORCID: https://orcid.org/0000-0003-1704-6219)
- Angela Ma
- Gerard Pasterkamp (ORCID: https://orcid.org/0000-0001-5345-1022)
- Nicholas J. Leeper (ORCID: https://orcid.org/0000-0002-0905-2806)
- Manja Meggendorfer (ORCID: https://orcid.org/0000-0002-9038-3265)
- Matthias Graw
- Ingo Hilgendorf (ORCID: https://orcid.org/0000-0002-0024-1643)
- Wolfgang Kern (ORCID: https://orcid.org/0000-0002-6452-2874)
- Dario Bongiovanni (ORCID: https://orcid.org/0000-0002-4162-1482)
- J. Brett Heimlich (ORCID: https://orcid.org/0000-0003-2812-5326)
- Sander W. van der Laan (ORCID: https://orcid.org/0000-0001-6888-1404)
- Florian Bassermann (ORCID: https://orcid.org/0000-0003-4435-2609)
- Andreas M. Zeiher (ORCID: https://orcid.org/0000-0003-1711-5819)
- Judith S. Hecker (ORCID: https://orcid.org/0000-0002-1531-0517)
- Johan Björkegren (ORCID: https://orcid.org/0000-0003-1945-7425)
- Florian Leuschner (ORCID: https://orcid.org/0000-0003-1157-474X)
- Salvatore Cassese (ORCID: https://orcid.org/0000-0002-8668-4313)
- Arno Ruusalepp (ORCID: https://orcid.org/0000-0001-5816-8613)
- Kaylin C.A. Palm (ORCID: https://orcid.org/0000-0002-0816-8962)
- Siddhartha Jaiswal (ORCID: https://orcid.org/0000-0002-9597-0477)
- Julia Fleig
- Michal Mokrý (ORCID: https://orcid.org/0000-0002-5298-4852)
- Matthias Schwab
- Felix Voll (ORCID: https://orcid.org/0000-0003-1034-6147)
- Sophia Steigerwald (ORCID: https://orcid.org/0000-0002-7513-1131)
- Moritz von Scheidt (ORCID: https://orcid.org/0000-0001-7159-8271)
- Sebastian Cremer (ORCID: https://orcid.org/0000-0002-6409-9279)
- Sabine Bauer (ORCID: https://orcid.org/0000-0001-7929-8417)
- Jason C. Kovacic (ORCID: https://orcid.org/0000-0003-4555-769X)
- Matthias Mann (ORCID: https://orcid.org/0000-0003-1292-4799)
- Lilith Oldenbuettel
- Zhifen Chen (ORCID: https://orcid.org/0000-0002-1622-2105)
- Christian Frieß
- Charalampos Sofokleous
Institutions
- Goethe University Frankfurt (DE)
- Augsburg University (US)
- Karolinska University Hospital (SE)
- Humanitas University (IT)
- University of Augsburg (DE)
- Utrecht University (NL)
- Victor Chang Cardiac Research Institute (AU)
- Heidelberg University (DE)
- Cardiovascular Institute of the South (US)
- Frankfurt Institute for Advanced Studies (DE)
- University Hospital Augsburg (DE)
- Tartu University Hospital (EE)
- TUM Klinikum (DE)
- Karolinska Institutet (SE)
- University Medical Center Utrecht (NL)
- LMU Klinikum (DE)
- UNSW Sydney (AU)
- Munich Leukemia Laboratory (Germany) (DE)
- Deutsches Herzzentrum der Charité (DE)
- St Vincent's Clinic (AU)
- German Centre for Cardiovascular Research (DE)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
- Stanford Medicine (US)
- Deutsches Herzzentrum München (DE)
- Max Planck Institute of Biochemistry (DE)
- DKFZ-ZMBH Alliance (DE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Clinical Gene Networks (Sweden) (SE)
- University of Tartu (EE)
- Ludwig-Maximilians-Universität München (DE)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1093/eurheartj/ehaf602
- Citations
- 6
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 10.62
Funders
- American Heart Association
- Deutsches Zentrum für Herz-Kreislaufforschung
- Corona-Stiftung
- European Commission
- Deutsche Forschungsgemeinschaft
- Fondation Leducq
- Bundesministerium für Bildung und Forschung
- Vetenskapsrådet
- Deutsche Herzstiftung
- NSW Ministry of Health
- Servier
- National Institutes of Health
- National Heart, Lung, and Blood Institute