Time-varying impact of established prognostic factors in resected pancreatic ductal adenocarcinoma
The impact of prognostic factors in resected PDAC across NAT and US patients is time-varying. Our results suggest that aggressive disease drives early mortality but, after NAT, tumor-biological factors lose prognostic importance to frailty and comorbidities over time.
Authors
- Casper H.J. van Eijck (ORCID: https://orcid.org/0000-0002-9511-2157)
- Greg D. Sacks (ORCID: https://orcid.org/0000-0003-1205-6477)
- Hjalmar C. van Santvoort (ORCID: https://orcid.org/0009-0007-1218-2883)
- Marc G. Besselink (ORCID: https://orcid.org/0000-0003-2650-9350)
- Maarten W. Nijkamp (ORCID: https://orcid.org/0000-0002-5074-2032)
- J. Sven D. Mieog (ORCID: https://orcid.org/0000-0002-3649-8504)
- Kelly J. Lafaro (ORCID: https://orcid.org/0000-0002-7070-7269)
- Bas Groot Koerkamp (ORCID: https://orcid.org/0000-0003-1917-6973)
- Asad Saulat Fatimi (ORCID: https://orcid.org/0000-0002-4869-0683)
- Fabio Bagante (ORCID: https://orcid.org/0000-0002-5386-0958)
- Ingmar F. Rompen (ORCID: https://orcid.org/0000-0002-0257-1654)
- Olivier R. Busch (ORCID: https://orcid.org/0000-0001-9605-6831)
- Richard A. Burkhart (ORCID: https://orcid.org/0000-0003-1087-0870)
- Gijs A. Patijn
- Thomas F. Stoop (ORCID: https://orcid.org/0000-0003-3328-4516)
- Joseph R. Habib (ORCID: https://orcid.org/0000-0003-3445-2278)
- Brady A. Campbell (ORCID: https://orcid.org/0000-0002-0792-6928)
- Martijn W.J. Stommel (ORCID: https://orcid.org/0000-0002-4257-5254)
- Geert Kazemier (ORCID: https://orcid.org/0000-0002-9811-3497)
- Marcel den Dulk (ORCID: https://orcid.org/0000-0002-6161-161X)
- Daan J. Lips (ORCID: https://orcid.org/0000-0001-7515-9276)
- Omar Mahmud (ORCID: https://orcid.org/0000-0001-6514-1646)
- Erwin van der Harst (ORCID: https://orcid.org/0000-0002-1317-5614)
- Lois A. Daamen (ORCID: https://orcid.org/0000-0001-9227-7178)
- I Quintus Molenaar
- Ignace H. J. T. de Hingh (ORCID: https://orcid.org/0000-0003-3491-4268)
- Eric R. Manusama
- Nabeela Mughal (ORCID: https://orcid.org/0000-0001-8013-5412)
- D. Brock Hewitt (ORCID: https://orcid.org/0000-0001-6556-3830)
- Thijs J. Schouten (ORCID: https://orcid.org/0000-0001-6223-5719)
- Freek Daams (ORCID: https://orcid.org/0000-0001-6323-6342)
- P. Andel (ORCID: https://orcid.org/0009-0006-9341-9282)
- Ammar A. Javed (ORCID: https://orcid.org/0000-0002-5463-5250)
- Iris W.J.M. van Goor (ORCID: https://orcid.org/0000-0003-3770-9841)
- Jin He
- William R. Burns (ORCID: https://orcid.org/0000-0002-3049-4377)
- Christopher L. Wolfgang (ORCID: https://orcid.org/0000-0002-8717-0373)
- Joost M. Klaase
- Sebastiaan Festen
- Jan H. Wijsman
Institutions
- University Medical Center Groningen (NL)
- Johns Hopkins University (US)
- Radboud University Nijmegen (NL)
- Heidelberg University (DE)
- Johns Hopkins Medicine (US)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Catharina Ziekenhuis (NL)
- Medisch Spectrum Twente (NL)
- Erasmus MC (NL)
- University Hospital Heidelberg (DE)
- Medisch Centrum Leeuwarden (NL)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Maastricht University (NL)
- NYU Langone Health (US)
- St. Antonius Ziekenhuis (NL)
- OLVG (NL)
- Amphia Ziekenhuis (NL)
- Maasstad Ziekenhuis (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Cancer Genomics Centre (NL)
- Aga Khan University (TZ)
- Isala (NL)
- Amsterdam University Medical Centers (NL)
- Cancer Center Amsterdam (NL)
- New York University (US)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-07-18
- DOI
- https://doi.org/10.1093/jnci/djaf196
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Herb Kosten Foundation