Enhancement of Doxorubicin Efficacy in Drug‐Resistant Breast Cancer Cells Through Nucleic Acid Modulation
Abstract Multidrug resistance (MDR) significantly limits breast cancer chemotherapy effectiveness. Here, we engineered a hyaluronic acid–functionalized graphene oxide (HA‐GO) nanocarrier for co‐delivery of microRNA‐489 and MDR1 antisense oligonucleotide (ASO, MB1) alongside doxorubicin (DOX). Among various nucleic acid ratios, a MiR‐489:MDR1 ASO ratio of 2:1 exhibited the most potent enhancement of DOX sensitivity in MCF‐7/ADM cells. This co‐delivery system synergistically reduced drug resistance, increased intracellular DOX accumulation, and amplified cytotoxicity. These results highlight the optimized HA‐GO platform as a promising strategy to overcome MDR in breast cancer therapy.
Authors
- Zhaoqi Yang (ORCID: https://orcid.org/0000-0002-4485-8872)
- Yuxuan Qian (ORCID: https://orcid.org/0000-0002-0164-732X)
- Yanfei Cai
- Yazhou Liu (ORCID: https://orcid.org/0000-0002-0135-210X)
- Ziyu Wei (ORCID: https://orcid.org/0000-0002-3094-3857)
Institutions
- Jiangnan University (CN)
Publication Details
- Journal
- ChemistrySelect
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/slct.202501703
- Primary Topic
- Graphene and Nanomaterials Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00