Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26
We reveal that ET restores the autophagic flux in macrophages, inhibit NLRP3 inflammasome activation, and mitigate inflammatory damage in septic mice, potentially through the regulation of TRIM26.
Authors
- Yuchun Jiang
- Youran Chen
- Mingqin Lu (ORCID: https://orcid.org/0000-0002-8331-5862)
- Xueting Xie
- Minghao Lin
- Cha Shen
- Yanyan Yang (ORCID: https://orcid.org/0000-0002-6927-1904)
- Naibin Yang
- Shiwen Wu (ORCID: https://orcid.org/0000-0003-1023-4073)
- Shanshan Li (ORCID: https://orcid.org/0000-0001-5264-7170)
- Sijie Zheng (ORCID: https://orcid.org/0009-0000-8792-0245)
- Huifang Shi
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Nanjing Traditional Chinese Medicine Hospital (CN)
- Ningbo University Affiliated Hospital (CN)
- Ningbo First Hospital (CN)
Publication Details
- Journal
- Open Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1515/med-2025-1231
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wenzhou Medical University
- Wenzhou Municipal Science and Technology Bureau
- Natural Science Foundation of Zhejiang Province