Combined hamartoma of the retina and retinal pigment epithelium: unusual rapid progression and early surgical intervention

We report a case of a young woman who presented with a vitreous haemorrhage associated with a combined hamartoma of the retina and retinal pigment epithelium (CHRRPE). During her clinical course, while the vitreous haemorrhage resolved, the lesion enlarged with a worsening epiretinal membrane. The patient's visual acuity reduced from 0.06 to 0.4 logMAR (Snellen equivalent of 6/7.5 to 6/30) with worsening metamorphopsia over a 13-week period. She shortly underwent pars plana vitrectomy with a membrane peel with an improved anatomical and visual outcome.The case presented shows an uncommon presentation of CHRRPE in a patient with rapid clinical progression, highlighting the favourable outcomes of early surgery.

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Publication Details

Journal
BMJ Case Reports
Published
2025-09-01
DOI
https://doi.org/10.1136/bcr-2025-265939
Primary Topic
Retinal and Macular Surgery
Type
article
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article

Combined hamartoma of the retina and retinal pigment epithelium: unusual rapid progression and early surgical intervention

George Moussa, Sandra Banderas, Guillermo De La Mata, Shari Cadogan
1 links
BMJ Case Reports
Retinal and Macular Surgery
article

Combined hamartoma of the retina and retinal pigment epithelium: unusual rapid progression and early surgical intervention

George Moussa, Sandra Banderas, Guillermo De La Mata, Shari Cadogan
article en

Abstract

We report a case of a young woman who presented with a vitreous haemorrhage associated with a combined hamartoma of the retina and retinal pigment epithelium (CHRRPE). During her clinical course, while the vitreous haemorrhage resolved, the lesion enlarged with a worsening epiretinal membrane. The patient's visual acuity reduced from 0.06 to 0.4 logMAR (Snellen equivalent of 6/7.5 to 6/30) with worsening metamorphopsia over a 13-week period. She shortly underwent pars plana vitrectomy with a membrane peel with an improved anatomical and visual outcome.The case presented shows an uncommon presentation of CHRRPE in a patient with rapid clinical progression, highlighting the favourable outcomes of early surgery.

BMJ Case ReportsVol. 18(9)
Manchester Royal Eye Hospital (GB), Milton Keynes Hospital (GB)
Openalex Percentile: Top 67%
Retinal and Macular Surgery
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