Clinical Efficacy and Safety of Omadacycline Versus Tigecycline in Treating Severe Pneumonia Caused by Carbapenem-Resistant Gram-Negative Bacilli: A Retrospective Cohort Study
Our study found that omadacycline is comparable to tigecycline in clinical effectiveness for the treatment of CRGNB-associated severe pneumonia, while exhibiting a better safety profile. Novel tetracyclines may be used in combination with β-lactams for the treatment of severe pneumonia caused by CRGNB.
Authors
- Wenhui Xu (ORCID: https://orcid.org/0000-0002-9490-0207)
- Yueping Ding (ORCID: https://orcid.org/0000-0001-7746-1567)
- Min Wang (ORCID: https://orcid.org/0000-0002-2479-6096)
- Fei Wang (ORCID: https://orcid.org/0000-0002-5676-2181)
- Aiping Wang (ORCID: https://orcid.org/0000-0003-3392-0543)
- Ye Zhang
Institutions
- Zhejiang Chinese Medical University (CN)
- Wenzhou Medical University (CN)
- Dongyang People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/idr.s541192
- Citations
- 1
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.35