Perturbances in Both Circulating B and CD4 <sup>+</sup> T Cells Discriminate Multiple Sclerosis from Other Central Nervous System Autoimmune Diseases
Using spectral flow cytometry, we analyzed circulating lymphocyte subsets in treatment-naive individuals with multiple sclerosis (MS) and other central nervous system autoimmune diseases (CNS AIDs). Elevated B-cell and CD4<sup>+</sup> T-cell frequencies were a disease-specific feature of MS, while reduced T-bet<sup>+</sup> and CXCR3<sup>+</sup> B-cell levels were associated with progressive disease.
Authors
- Beatrijs Wokke (ORCID: https://orcid.org/0000-0002-2616-8464)
- Laurens Bogers
- Jasper Rip (ORCID: https://orcid.org/0000-0001-5780-9271)
- Marie‐José Melief (ORCID: https://orcid.org/0000-0003-4625-4260)
- Kirsten L. Kuiper (ORCID: https://orcid.org/0009-0007-9562-4500)
- Marvin M. van Luijn (ORCID: https://orcid.org/0000-0002-1283-1018)
- Romy A. M. Klein Kranenbarg (ORCID: https://orcid.org/0009-0007-3460-9948)
- Joost Smolders (ORCID: https://orcid.org/0000-0001-9766-8661)
- Maarten J. Titulaer (ORCID: https://orcid.org/0000-0002-1033-3840)
- Suzanne C. Franken (ORCID: https://orcid.org/0009-0006-7582-5295)
- Annet F. Wierenga‐Wolf
- Cato E. A. Corsten (ORCID: https://orcid.org/0000-0001-6531-6979)
- Ide Smets (ORCID: https://orcid.org/0000-0001-8174-2898)
- Ana M. Marques
- Janet de Beukelaar
Institutions
- Netherlands Institute for Neuroscience (NL)
- Erasmus MC (NL)
- Albert Schweitzer Ziekenhuis (NL)
Publication Details
- Journal
- European Journal of Immunology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/eji.70049
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Stichting MS Research
- Stichting Dioraphte