Beyond serendipity: uncovering novel ratiometric urea·24DHBA cocrystals through mechanochemistry and MicroED
Mechanochemical synthesis of urea cocrystals with 2,4-dihydroxybenzoic acid (24DHBA) reveals two new stoichiometric forms: (urea)<sub>2</sub>·(24DHBA) and (urea)<sub>2</sub>·(24DHBA)<sub>2</sub>, not accessible <i>via</i> solution methods. The known (urea)<sub>0.5</sub>·(24DHBA) form remains the most stable. These findings provide critical insights into stoichiometric tuning of agro-cocrystals and pave the way for their practical application in sustainable agriculture.
Authors
- Takanori Nakane (ORCID: https://orcid.org/0000-0003-2697-2767)
- Genji Kurisu (ORCID: https://orcid.org/0000-0002-5354-0807)
- Akihiro Kawamoto (ORCID: https://orcid.org/0000-0002-7380-0127)
- Khaled Althubeiti (ORCID: https://orcid.org/0000-0001-7849-0925)
- Ranjit Thakuria (ORCID: https://orcid.org/0000-0002-0325-3316)
- Diptajyoti Gogoi (ORCID: https://orcid.org/0009-0004-3192-8933)
- Toshiyuki Sasaki (ORCID: https://orcid.org/0000-0002-2849-1900)
- Nabadeep Kalita
- Ankur Bonia
Institutions
- Gauhati University (IN)
- Taif University (SA)
- Japan Synchrotron Radiation Research Institute (JP)
- Protein Research Foundation (JP)
- University of Warsaw (PL)
- The University of Osaka (JP)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc03628c
- Citations
- 1
- Primary Topic
- Crystallography and molecular interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.75