Tumor inflammation-associated neurotoxicity in children with diffuse intrinsic pontine glioma receiving B7-H3-targeting CAR T cells on BrainChild-03
TIAN was common within this cohort but mostly low-grade and transient. Refining its classification and understanding its clinical impact will aid safety assessments and trial comparisons for CNS-directed CAR T therapies.
Authors
- Michael C. Jensen (ORCID: https://orcid.org/0000-0001-7477-3063)
- Julie R. Park (ORCID: https://orcid.org/0000-0002-6777-9165)
- Michelle Choe (ORCID: https://orcid.org/0000-0001-9850-9435)
- Juliane Gust
- Nicholas A. Vitanza (ORCID: https://orcid.org/0000-0002-3966-4985)
- Rebecca J. Ronsley (ORCID: https://orcid.org/0000-0003-3961-3042)
- Jason N. Wright (ORCID: https://orcid.org/0000-0002-6676-8253)
- Jason Wendler (ORCID: https://orcid.org/0000-0003-4195-8138)
- Amy Lee (ORCID: https://orcid.org/0000-0001-6205-6614)
- Kristy Seidel (ORCID: https://orcid.org/0000-0002-8402-0900)
- Colleen Annesley (ORCID: https://orcid.org/0000-0002-3473-0947)
Institutions
- Seattle Children's Hospital (US)
- St. Jude Children's Research Hospital (US)
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Seattle Children's Hospital (US)
- Center for Cancer and Blood Disorders (US)
- Allen Institute (US)
Publication Details
- Journal
- Neuro-Oncology Practice
- Published
- 2025-07-30
- DOI
- https://doi.org/10.1093/nop/npaf080
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05