Blocking Vagal Activity to Prevent Cancer-associated Cachexia

Major Finding: Blocking vagal hyperactivity in lung and pancreatic cancer restores liver function, improves cachexia features, and extends survival in preclinical models.Concept: Cancer-induced systemic inflammation drives vagal overactivity, suppressing hepatic HNF4α and promoting cachexia.Impact: Targeted vagal modulation offers a neurometabolic therapeutic avenue to slow cachexia progression and improve cancer survival.

Publication Details

Journal: Cancer Discovery
Published: 2025-01-01
DOI: https://doi.org/10.1158/2159-8290.cd-rw2025-080
Primary Topic: Nutrition and Health in Aging
Type: article
Field-Weighted Citation Impact: 0.00

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article

Blocking Vagal Activity to Prevent Cancer-associated Cachexia

Jan 1, 2025

Cancer Discovery

Nutrition and Health in Aging

article

Blocking Vagal Activity to Prevent Cancer-associated Cachexia

January 1, 2025article en

Abstract

Cancer Discovery

Openalex Percentile: Top 71%

Nutrition and Health in Aging

DOI Source OpenAlex

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Blocking Vagal Activity to Prevent Cancer-associated Cachexia · Cancer Discovery (2025) | TGRS Research Map | TGRS