Divergent responses of glutamatergic and GABAergic prefrontal neurons underlie changes in excitability following low and high frequency repetitive brain stimulation
These findings provide direct evidence that repetitive brain stimulation protocols used clinically can induce long-term modulation of prefrontal cortical excitability, with low-frequency stimulation inhibiting glutamatergic neurons and high-frequency stimulation inhibiting GABAergic neurons.
Authors
- Jyoti Mishra (ORCID: https://orcid.org/0000-0001-6612-4557)
- Jonathan Mishler (ORCID: https://orcid.org/0009-0004-6120-5525)
- Milad Nazari (ORCID: https://orcid.org/0000-0002-5008-5159)
- Dhakshin Ramanathan (ORCID: https://orcid.org/0000-0002-5212-3067)
- Morteza Salimi (ORCID: https://orcid.org/0000-0002-7621-6823)
Institutions
- UC San Diego Health System (US)
- Danish National Research Foundation (DK)
- VA San Diego Healthcare System (US)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.brs.2025.08.021
- Citations
- 2
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Burroughs Wellcome Fund
- Hope for Depression Research Foundation
- National Institute of Mental Health and Neurosciences