Looking beyond chronological age: the importance of frailty in biologic treatment efficacy in older individuals

Here, we comment on the study by Viviani et al., which evaluated the efficacy and safety of biologic treatments in older patients with psoriasis. We emphasize the importance of the concept of ‘frailty’ beyond chronological age and highlight that the Fried Frailty Index is a critical tool for assessing treatment response, risk–benefit analysis and individualized treatment approaches in older adults. We consider that for diseases such as psoriasis, which often present with comorbidities and require a multidisciplinary approach, using the Fried Frailty Index instead of chronological age would yield more holistic and meaningful results.