Nickel-catalyzed reductive cross-coupling of aziridines and benzyl chlorides
A nickel-catalyzed reductive cross-coupling of aziridines and benzyl chlorides was realized by using manganese metal as the reducing agent. This protocol afforded a convenient approach for obtaining β-benzyl-substituted arylethylamines bearing various functional groups. The utility of this reaction was also demonstrated by their straightforward conversion to privileged tetrahydroisoquinoline derivatives.
Authors
- Senlin Wang (ORCID: https://orcid.org/0009-0003-0597-4816)
- Chuanfu Liu (ORCID: https://orcid.org/0000-0002-3151-7956)
- Jie Wan
- Yu-Lu Chen
- Bi‐Qin Wang
- Ping Hu (ORCID: https://orcid.org/0000-0003-4180-4630)
- Bin Chen (ORCID: https://orcid.org/0000-0002-9907-7002)
- Peng Cao (ORCID: https://orcid.org/0000-0001-8199-0015)
- Hai‐Liang Ni (ORCID: https://orcid.org/0009-0000-1667-6214)
Institutions
- Chengdu Normal University (CN)
- Sichuan Normal University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01299f
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00