Sirolimus Plus Low‐Exposure Calcineurin Inhibitors as an Alternative Graft‐Versus‐Host Disease Prophylaxis in Calcineurin Inhibitor‐Intolerant Recipients: A Retrospective Study
For allo-HSCT recipients with CNI intolerance, this study provides the first evaluation of sirolimus combined with low-exposure CNIs as a GvHD prophylaxis. Our findings suggest this regimen is a promising and feasible alternative, although validation in larger, prospective studies is warranted.
Authors
- Yongrong Lai (ORCID: https://orcid.org/0000-0002-0371-1719)
- Zhenbin Wei (ORCID: https://orcid.org/0000-0003-2197-2047)
- Lingling Shi
- Yanfei Lu
- Min Wu (ORCID: https://orcid.org/0009-0007-3527-4262)
- Rongrong Liu
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Fourth Affiliated Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Clinical Transplantation
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/ctr.70306
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00