The Role of Antipsychotic Treatments in Neutrophil/Lymphocyte, Platelet/Lymphocyte, Monocyte/Lymphocyte, Monocyte/HDL Ratios and Systemic Immune Inflammatory Index Values for Patients with Schizophrenia

ABSTRACT Backround/Aims: Abnormal systemic inflammatory responses play a significant role in pathogenesis of schizophrenia. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), monocyte-HDL ratio (MHR) and systemic immune inflammation index (SII) have recently been used as markers of inflammation. The aim of our study is to examine the relationship between NLR, PLR, MLR, MHR, and SII values of patients diagnosed with schizophrenia and antipsychotic treatments. Methods: One hundred ninety four individuals diagnosed with schizophrenia who were followed up in Psychotic Disorders Polyclinic of the Selcuk University Faculty of Medicine, were included in the study. Neutrophil, lymphocyte, platelet and monocyte counts, HDL values were obtained retrospectively from blood tests. NLR, PLR, MLR, MHR, and SII were calculated. Results: The mean age of patients was 44.38 ± 12.67 years. In total, 85 (43.8 %) patients were female. PLR, and SII were statistically significantly greater in females than in male group (p