The role of Vitamin D supplement to clomiphene citrate for induction of ovulation in overweight PCOS women

Polycystic Ovary Syndrome (PCOS) is a common endocrine illness leading to infertility in women.Clomiphene Citrate (CC) is a common medication used to induce ovulation in women with PCOS, but due to the presence of hyperinsulinemia, it can sometimes be effective, especially in overweight individuals with PCOS.Furthermore, obesity exacerbates vitamin D deficiency in women with PCOS and has been linked to insulin resistance and other PCOS symptoms.Such, the object of this study is to better understand how vitamin D supplementation can enhance ovulation induction with clomiphene citrate in overweight women with PCOS who are resistant to clomiphene citrate.In a double-blind study involving 220 PCOS patients, it was found that the pregnancy rate with vitamin D supplementation plus CC was somewhat higher (if not statistically significant).The hormonal profile and demographics of both groups were fairly similar.Complications were similar except there were more nausea and vomiting in the vitamin D group.Although further research with larger sample sizes is necessary to investigate these trends, this study suggests that vitamin D supplementation may possibly have a role in ovulation induction in overweight PCOS women.Supplementation with vitamin D could represent a potential adjunctive therapy for the treatment of PCOS; however, further research is required to definitively assess its value.