Integrated Single‐Cell <scp>RNA</scp> ‐Seq Reveals Immunosuppressive Mechanisms of Treg Cell Differentiation and Tumor Microenvironment Interactions in Colorectal Cancer
Collectively, TGFβ1<sup>+</sup> Treg may mediate CD8<sup>+</sup> T cell dysfunction through these ligand-receptor interactions, accelerating T cell exhaustion and apoptosis, thereby fostering a profoundly immunosuppressive tumor microenvironment that ultimately drives CRC immune evasion and malignant progression.
Authors
- Jingya Liu
- Ronghui Chen
- Xiaohe Luo (ORCID: https://orcid.org/0000-0002-7951-9002)
- Li Yu (ORCID: https://orcid.org/0000-0002-3893-8876)
- Dongwei Li (ORCID: https://orcid.org/0000-0002-9970-5689)
- Xiaomei Wu (ORCID: https://orcid.org/0000-0003-2915-3513)
Institutions
- Wenzhou Medical University (CN)
- Tung Wah Hospital (CN)
- EA Technology (GB)
- Guangzhou Vocational College of Science and Technology (CN)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- Dongguan People’s Hospital (CN)
- Dongyang People's Hospital (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/cam4.71202
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81