Subcutaneous Allergen‐Specific Immunotherapy for Allergic Rhinitis: Divergent IgA Responses in Nasal Mucosa and Blood With Validation of B Cell Class‐Switching in Lymph Nodes and Blood
This study highlights the differential effects of SCIT on local and systemic immunity and identifies early immunological changes associated with treatment. However, confirmation of long-term tolerance will require extended follow-up, including in-season analyses. The local decrease in allergen-specific IgA in NAL, alongside a systemic increase in allergen-specific IgA and IgG4, underscores the importance of assessing both mucosal and systemic responses when evaluating SCIT efficacy.
Authors
- Eduardo I. Cardenas (ORCID: https://orcid.org/0000-0001-5973-5675)
- Maryam Jafari
- Laila Hellkvist
- Agnetha Karlsson
- Marianne Petro (ORCID: https://orcid.org/0009-0005-1996-1199)
- Eric Hjalmarsson (ORCID: https://orcid.org/0009-0007-7228-6131)
- Lars‐Olaf Cardell (ORCID: https://orcid.org/0000-0003-0538-9580)
- Susanna Kumlien Georén (ORCID: https://orcid.org/0000-0001-7292-9255)
- Monika Ezerskyte (ORCID: https://orcid.org/0009-0000-2196-355X)
- Eirini Paziou
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Clinical and Translational Allergy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/clt2.70097
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vetenskapsrådet