Catalytic asymmetric kinetic resolution of 2-ethynylaziridines <i>via</i> nucleophilic ring opening with amines
The enantioselective kinetic resolution of racemic 2-ethynylaziridines <i>via</i> ring opening with amines is realized under the catalysis of a chiral Cu(I)-bisphosphine combination. This protocol provides an expedient way to access synthetically valuable enantioenriched propargylic vicinal diamines (70%-95% yields, 14%-95% ee) and 2-ethynylaziridines (70%-95% recovery rates, 14%-95% ee) within 15-240 h under mild reaction conditions.
Authors
- Zhuo Chai (ORCID: https://orcid.org/0000-0002-9878-8814)
- Wentao Ji (ORCID: https://orcid.org/0000-0002-2085-7007)
- Tingting Cheng (ORCID: https://orcid.org/0000-0003-0103-2242)
- Yao Li (ORCID: https://orcid.org/0000-0002-4523-8368)
Institutions
- Anhui Normal University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01270h
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00