Metabolomic Signatures and Predictive Utility of LOXL1-Associated Genetic Risk Scores for Exfoliation Syndrome/Glaucoma in US Cohorts
XFS GRS8 improved XFGS/XFG prediction, and a higher XFS GRS8 was associated with altered levels of fatty acyl and bile acid metabolite classes.
Authors
- Louis R. Pasquale (ORCID: https://orcid.org/0000-0002-5835-3496)
- Jae H. Kang (ORCID: https://orcid.org/0000-0003-4812-0557)
- Oana A. Zeleznik (ORCID: https://orcid.org/0000-0002-8705-1163)
- Janey L. Wiggs (ORCID: https://orcid.org/0000-0003-1890-3278)
- Namuunaa Juramt
Institutions
- Brigham and Women's Hospital (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Metabolites
- Published
- 2025-08-30
- DOI
- https://doi.org/10.3390/metabo15090582
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Glaucoma Foundation
- National Institutes of Health