SERVICE EVALUATION TO ASSESS IMPACT OF SOCIOECONOMIC STATUS (SES) ON ACCESS TO TREATMENT AND DISEASE OUTCOMES IN ANALYSIS OF LITERATURES

Abstract AIMS It has recently been reported that survival in IDH-wildtype glioblastoma (GBM) is can be associated with eco- nomic income. Data informing this predominantly published from insurance-based healthcare systems. We explored socioeconomic status (SES) impact on treatment access and overall survival (OS) within NHS infras- tructure and at a single tertiary UK Neuro-oncology centre. METHODS Retrospective observational study of patients with histopathological diagnosis of GBM between 19/02/2021– 19/03/2023. Data collected using electronic patient records. To determine SES, index of multiple deprivation decile (IMDD) collected based on postcode and obtained using the English indices of deprivation 2019. OS de- fined as time from initial diagnostic imaging to death. Descriptive statistics utilised Excel. Univariate analysis using Kaplan-Meier method, Chi-squared for comparisons using R statistical language. RESULTS 211 patients were included with 16 excluded due incomplete data. Median age of 64 years, 64.9% male. Median IMDD decile 7 (lower quartile 5, upper quartile 9). When stratified around median IMDD decile (<7³7) there were no significant differences in treatments between groups (radiotherapy dose-fractionation, chemotherapy, extent of surgical resection). Comparison of upper and lower quartiles (IMDD£ 5 vs ³9) differences remains in- significant except radiotherapy dose-fractionation (p=0.043) where lower (SES) quartile group were more likely to receive 60Gy in 30 fractions. Reassuring, IMDD did not associate significantly with mOS on univariate analysis (p>0.5). CONCLUSION Despite published suggests lower SES is associated with poorer mOS and less aggressive treatment. Local data does not support this. This is reassuring that access to treatment appears equitable within the NHS framework and there are no survival differences.