Adherence to recombinant human growth hormone therapy in children: influencing factors and clinical implications

Adherence to rhGH therapy is influenced by multiple factors, including GH formulation, age, severity of growth deficit, treatment duration, and regional disparities. Long-acting GH formulations significantly improve adherence. Tailored interventions, such as parental education, digital adherence monitoring, and personalized support programs, are essential to sustain long-term adherence and optimize treatment outcomes.