Systemic and Mucosal Immune Responses Induced by Adenoviral-Vectored Consensus H5 Influenza A Vaccines in Mice and Swine
Adenoviral-vectored H5CC vaccines elicit broad, cross-clade immunity with route-dependent immune profiles. IM vaccination is optimal for systemic and cellular responses, while IN delivery enhances mucosal immunity. These findings support the advancement of adenoviral platforms for influenza control in swine and pandemic preparedness.
Authors
- Richard J. Webby (ORCID: https://orcid.org/0000-0002-4397-7132)
- Jennifer DeBeauchamp
- Eric A. Weaver (ORCID: https://orcid.org/0000-0002-5029-0662)
- Adthakorn Madapong (ORCID: https://orcid.org/0000-0003-4007-4920)
- Joshua Wiggins (ORCID: https://orcid.org/0000-0002-8574-5073)
Institutions
- University of Nebraska–Lincoln (US)
- St. Jude Children's Research Hospital (US)
Publication Details
- Journal
- Vaccines
- Published
- 2025-08-30
- DOI
- https://doi.org/10.3390/vaccines13090928
- Citations
- 1
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Institutes of Health