Biomimetic nanoparticles coated with ScFv-modified macrophage membranes for siRNA delivery to relieve brain metastases of lung cancer
Our findings suggest that scFv-MML@LPCAT1si represents a promising targeted therapy for NSCLC BM, leveraging the unique properties of scFv-MML to traverse the BBB and deliver therapeutic payloads to tumor sites with high accuracy and efficiency.
Authors
- Jun Jiang (ORCID: https://orcid.org/0000-0002-8931-9872)
- Jianjun Shi (ORCID: https://orcid.org/0000-0001-6383-0974)
- Yijing Zhang (ORCID: https://orcid.org/0000-0002-5671-2520)
- Ting Wu (ORCID: https://orcid.org/0000-0003-3081-8092)
- Yuan Lu (ORCID: https://orcid.org/0000-0002-9103-5211)
- Yan Qiao (ORCID: https://orcid.org/0000-0003-0888-2047)
Institutions
- Zhongda Hospital Southeast University (CN)
- The First People’s Hospital of Lianyungang (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- BMC Biotechnology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s12896-025-01000-5
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Key Research and Development Projects of Shaanxi Province