PANoptosis-mediated mechanisms underlying AST elevation in Talaromyces marneffei infection
Our findings demonstrate that T. marneffei infection triggers PANoptosis- mediated hepatocyte death and hepatic inflammatory activation, which contributes to AST elevation. AST may serve as a potential auxiliary biomarker for early diagnosis and therapeutic monitoring in Talaromycosis.
Authors
- Xiao-Tao He (ORCID: https://orcid.org/0000-0003-1897-0892)
- Gang Wang (ORCID: https://orcid.org/0000-0001-7264-2457)
- Junjun Jiang (ORCID: https://orcid.org/0000-0003-4905-9348)
- Wudi Wei (ORCID: https://orcid.org/0000-0001-6703-4529)
- Baili Zhan (ORCID: https://orcid.org/0009-0007-7639-7824)
- Xiuli Bao
- Hao Liang (ORCID: https://orcid.org/0000-0001-7534-5124)
- Weihong Huang (ORCID: https://orcid.org/0000-0002-7168-4943)
- Li Ye (ORCID: https://orcid.org/0000-0001-7688-4867)
- Lixiang Chen (ORCID: https://orcid.org/0000-0001-7785-2496)
- Xiaoting Xie (ORCID: https://orcid.org/0000-0002-3779-4786)
- Zhiman Xie
- Meng Zhang (ORCID: https://orcid.org/0009-0004-5279-5164)
Institutions
- Guangxi Medical University (CN)
- The Fourth People's Hospital (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1371/journal.pntd.0013443
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China