Phenolic-rich extracts of Teucrium oliverianum confer protection against thioacetamide-induced liver fibrosis in rats: Insights from metabolomics, biochemical and histopathological analysis
This study provides robust evidence supporting the antifibrotic effects of T. oliverianum in a TAA-induced liver injury model. The anti-proliferative activity and hepatoprotective effects are likely to be mediated by its richness in phenolic acids, flavonoids and phenylethanoids.
Authors
- Rania Elgohary (ORCID: https://orcid.org/0000-0002-2948-5449)
- Abdelbaset M. Elgamal (ORCID: https://orcid.org/0000-0001-7060-0077)
- Abdelsamed I. Elshamy (ORCID: https://orcid.org/0000-0003-3302-3623)
- Ahmed M. Abd‐ElGawad (ORCID: https://orcid.org/0000-0002-5903-6329)
- Noha A. Mowaad (ORCID: https://orcid.org/0000-0002-1566-6214)
- Mohamed A. El-Saied (ORCID: https://orcid.org/0000-0002-3143-6953)
- Heba A. S. El‐Nashar (ORCID: https://orcid.org/0000-0003-4252-7647)
- Hiroshi Imagawa (ORCID: https://orcid.org/0000-0003-0708-713X)
- Mohamed A. Farag
- Rania F. Ahmed
Institutions
- Ain Shams University (EG)
- Cairo University (EG)
- King Saud University (SA)
- National Research Centre (EG)
- Tokushima Bunri University (JP)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1371/journal.pone.0330595
- Citations
- 2
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- King Saud University