Caspase-9 activates β-catenin signaling to promote pulmonary fibrosis
Caspase-9 drives pulmonary fibrosis by promoting epithelial apoptosis and activating β-catenin signaling. Targeting the Caspase-9/β-catenin axis may offer a promising therapeutic strategy for PF.
Authors
- Hongzuo Chen
- Bei Qing (ORCID: https://orcid.org/0000-0003-4740-2923)
- Ying Chen
- Linguo Gu
- Zhenkun Xia (ORCID: https://orcid.org/0000-0001-8923-0504)
- Juan Wang (ORCID: https://orcid.org/0000-0001-8724-9850)
- Yunchang Yuan
- Yaling Tang (ORCID: https://orcid.org/0000-0002-2405-2855)
- Rui Hu (ORCID: https://orcid.org/0000-0002-5081-2256)
- Zhenglian Ge
Institutions
- Central South University (CN)
- Hunan Cancer Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s12967-025-07020-1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Key Program of NSFC-Tongyong Union Foundation