Identification of gene-sex hormone interactions associated with type 2 diabetes among men and women
Including interaction terms in GWAS may identify additional risk loci and improve the understanding of genetic architecture for type 2 diabetes. Different genetic interactions with sex hormones in men and women emphasize the importance of sex-stratified analysis in sex differential diseases.
Authors
- Yan V. Sun (ORCID: https://orcid.org/0000-0002-2838-1824)
- Marta Gwinn (ORCID: https://orcid.org/0000-0002-7706-5174)
- Qin Hui (ORCID: https://orcid.org/0000-0002-8421-3518)
- Jin J. Zhou (ORCID: https://orcid.org/0000-0001-7983-0274)
- Amonae Dabbs‐Brown
- Chang Liu (ORCID: https://orcid.org/0000-0002-8620-9424)
- Peter W.F. Wilson
Institutions
- Emory University (US)
- University of California, Los Angeles (US)
- Phoenix VA Health Care System (US)
- Atlanta VA Health Care System (US)
Publication Details
- Journal
- PLoS Genetics
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1371/journal.pgen.1011470
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- NHLBI Division of Intramural Research