Defining metabolic abnormalities in acute human traumatic brain injury with cerebral microdialysis and multimodality monitoring
Many acute traumatic brain injury patients constantly demonstrate neurometabolic derangements, among which clinical mitochondrial dysfunction is highly prevalent despite normal cerebral pressure, oxygenation, and perfusion. There is necessity for targeted, neurometabolic therapies in neurocritical care that address this abnormality.
Authors
- Caroline Lindblad (ORCID: https://orcid.org/0000-0003-4952-8597)
- Mathew R. Guilfoyle
- Ivan Timofeev (ORCID: https://orcid.org/0000-0002-1168-0393)
- Keri L.H. Carpenter (ORCID: https://orcid.org/0000-0001-8236-7727)
- Peter J. Hutchinson (ORCID: https://orcid.org/0000-0002-2796-1835)
- Sara Venturini (ORCID: https://orcid.org/0000-0002-9541-0090)
- Adel Helmy (ORCID: https://orcid.org/0000-0002-0531-0556)
- M Baker
- Joshua M. Heihre
Institutions
- Uppsala University (SE)
- University of Cambridge (GB)
- Karolinska Institutet (SE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1371/journal.pone.0331310
- Citations
- 1
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.39