Real-World Effectiveness of Nirmatrelvir–Ritonavir Against Severe Outcomes of COVID-19 in Taiwan: A Nationwide Population-Based Cohort Study
In a large, nationally representative cohort, outpatient use of nirmatrelvir-ritonavir was associated with a significantly lower risk of severe COVID-19-related outcomes, regardless of age or vaccination status. These findings reinforce the clinical value of early antiviral treatment, particularly in aging and unvaccinated populations.
Authors
- Wanchi Chen
- Shan‐Chwen Chang (ORCID: https://orcid.org/0000-0001-6505-4139)
- Wen‐Yi Shau (ORCID: https://orcid.org/0000-0003-3977-1729)
Institutions
- National Taiwan University (TW)
- National Taipei University of Nursing and Health Science (TW)
- National Taiwan University Hospital (TW)
- National Taipei University of Business (TW)
- National Taipei University (TW)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1093/ofid/ofaf553
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- National Science and Technology Council