Isoflurane Exposure Influence on Sleep Architecture in a Rat Model of Alzheimer’s Disease
Isoflurane affected the sleep architecture in the transgenic model for studying Alzheimer disease. The prolonged time to ambulation, the more fragmented SLEEP/WAKE behavior, and the relative hyperactivity compared to age-matched control rats may imply that Alzheimer disease diminishes the brain's dynamic range to adapt to altered levels of consciousness.
Authors
- Paul S. García (ORCID: https://orcid.org/0000-0001-5544-6251)
- Matthias Kreuzer (ORCID: https://orcid.org/0000-0003-2472-3556)
- Christopher G. Sinon (ORCID: https://orcid.org/0000-0003-2961-7269)
- Gerhard Schneider (ORCID: https://orcid.org/0000-0002-4903-0118)
- Glenda L. Keating
- Thomas Fenzl (ORCID: https://orcid.org/0000-0002-0132-9591)
- David B. Rye
Institutions
- Emory University (US)
- Atlanta VA Medical Center (US)
- Technical University of Munich (DE)
- Columbia University (US)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-08-29
- DOI
- https://doi.org/10.1213/ane.0000000000007717
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00