Relationship Between Brain Activity and Impaired Consciousness in Frontal Lobe Seizures
The widespread power increases across frequencies in frontal lobe FIC seizures contrast with those in focal temporal lobe epilepsy, where impaired consciousness is associated with cortical slow waves. These findings suggest that different focal seizure types produce impaired consciousness by affecting widespread cortical regions but through different physiologic mechanisms. Insights gained by studying the physiology of impaired consciousness may be the first step toward developing novel treatments to prevent this significant negative consequence of epilepsy and improve quality of life.
Authors
- Avisha Kumar
- Jennifer Bonito
- Pue Farooque
- Jason L. Gerrard (ORCID: https://orcid.org/0000-0001-6971-1407)
- Christopher Andrew Arencibia
- Ilena George (ORCID: https://orcid.org/0000-0001-7863-8539)
- Jennifer Shum (ORCID: https://orcid.org/0000-0002-1893-1538)
- James Young (ORCID: https://orcid.org/0000-0001-9349-7519)
- Eric H. Grover
- Eyiyemisi C. Damisah (ORCID: https://orcid.org/0000-0001-8854-1335)
- Hal Blumenfeld (ORCID: https://orcid.org/0000-0003-0812-8132)
- Rahiwa Z. Gebre
- Eliezer J. Sternberg
- Jiayin Qu (ORCID: https://orcid.org/0009-0006-5277-8422)
- Ji Yeoun Yoo (ORCID: https://orcid.org/0000-0001-7242-9779)
- Monica Dhakar
- Imran H. Quraishi (ORCID: https://orcid.org/0000-0003-2859-7446)
- Elaheh Salardini
- Aparna Vaddiparti (ORCID: https://orcid.org/0000-0002-1709-4440)
- Hitten P. Zaveri (ORCID: https://orcid.org/0000-0001-7830-0052)
- Daniel Friedman (ORCID: https://orcid.org/0000-0003-1068-1797)
- Adithya Sivaraju (ORCID: https://orcid.org/0000-0002-6027-9205)
- Kun Wu (ORCID: https://orcid.org/0000-0001-5396-8187)
- Lawrence J. Hirsch (ORCID: https://orcid.org/0000-0002-6333-832X)
- Shamma Ahammad
- Leah M Gober
- Dennis D. Spencer (ORCID: https://orcid.org/0000-0002-1716-9887)
- Reese Martin
- Shivani Ghoshal (ORCID: https://orcid.org/0009-0008-3091-4942)
Institutions
- Yale University (US)
- New York University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1212/wnl.0000000000213965
- Primary Topic
- EEG and Brain-Computer Interfaces
- Type
- article
- Field-Weighted Citation Impact
- 0.00