Macrophage Nogo-B Drives Liver Fibrosis
Nogo-B facilitates liver fibrosis by recruiting the deubiquitination enzyme USP14, which increases the stabilization of RIPK3 and promotes NLRP3 inflammasome activation and necroptosis in macrophages.
Authors
- Liang Yuan (ORCID: https://orcid.org/0000-0002-2511-8561)
- Feng Cheng
- Jianhua Rao (ORCID: https://orcid.org/0000-0003-1222-7707)
- Ling Lü (ORCID: https://orcid.org/0000-0002-4983-5557)
- Ming Ni (ORCID: https://orcid.org/0000-0002-4402-7518)
- Lei Zhang
- Junda Li
- Mu Liu (ORCID: https://orcid.org/0000-0001-6434-2884)
- Long Zhang
- Yongquan Chi (ORCID: https://orcid.org/0009-0000-3509-0315)
- Wenzhu Li (ORCID: https://orcid.org/0000-0002-7031-4182)
- Jiahao Si (ORCID: https://orcid.org/0000-0002-0374-7404)
Institutions
- Xuzhou Medical College (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101622
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China